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A saturable and stereoselective neuronal binding site in rat brain tissue has been described for levetiracetamExperimental data indicate that this binding site is the synaptic vesicle protein SV2Athought to be involved in the regulation of vesicle exocytosisAlthough the molecular significance of levetiracetam binding to SV2A is not understoodlevetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity in audiogenic seizure-prone miceThese findings suggest that the interaction of levetiracetam with the SV2A protein may contribute to the antiepileptic mechanism of action of the drug.

KEPPRA1000 mg twice dailydid not influence the pharmacokinetics and pharmacodynamicsECGof digoxin given as a 0.25 mg dose every dayCoadministration of digoxin did not influence the pharmacokinetics of levetiracetam.

The overall adverse reaction profile of KEPPRA was similar between females and malesThere are insufficient data to support a statement regarding the distribution of adverse reactions by age and race.

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